【18th.May】New Basic Activation Modes Enabled by Carbene Organic Catalysts and Rapid Synthesis of Functional Molecules（氮雜卡賓(NHC)催化的新型活化模式與功能分子的簡潔合成）
日期：2016-05-18
閱讀：917
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TOPIC：New Basic Activation Modes Enabled by Carbene Organic Catalysts and Rapid Synthesis of Functional Molecules（氮雜卡賓(NHC)催化的新型活化模式與功能分子的簡潔合成）
SPEAKER：Prof. Yonggui Robin Chi (池永貴),Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, China (貴州大學(xué)精細化工研究開發(fā)中心)
Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore,E-mail: [email protected]; [email protected]
TIME：May 18 (Wednesday) AM10:00?
LOCATION：Room 528, Chemistry Building A (化學(xué)A樓528 演講廳)
INVITER：涂永強 院士
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New Basic Activation Modes Enabled by Carbene Organic Catalysts and Rapid Synthesis of Functional Molecules
氮雜卡賓(NHC)催化的新型活化模式與功能分子的簡潔合成
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The Chi laboratory is committed in state-of-art research that addresses synthetic chemistry challenges of scientific, economic, and social significance. Our essential objective is to develop fundamentally novel (organo) catalytic activation/reaction modes and synthetic strategies for the rapid (short route) synthesis of pharmaceuticals and other functional molecules that include polymer materials. Over the years, we have realized significant advancements in the design, discovery, and development of new basic activation modes enabled by N-heterocyclic carbenes (NHCs) as the key organic catalysts. With the new catalytic activation modes we hope to create new understanding of chemical reactivities and chemistry. Immediate applications of our new catalytic activation modes and synthetic strategies include concise and green processes for bioactive molecules such as valuable non-natural amino acids and their derivatives. We have also taken significant efforts in designing new molecular scaffold for applications in agriculture chemicals, and develop scalable methods for the synthesis and manufacturing of medicinal, agricultural, and other functional molecules.??
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Examples of our research activities include: (1) Carbene (NHC) organic catalyst-enabled activation of carboxylic esters (including
the inert beta-sp3-carbon activation of saturated esters); (2)New reaction controls of aldehydes under (oxidative) carbene catalysis; (3) Cooperative catalysis combining carbene organic catalysts with other catalysts (such as transition metal catalysts, Lewis acid catalysts, and other organic catalysts); (4)Biomimetic single-electron-transfer (SET) radical reactions enabled by carbene organic catalysts; (5) Multi-disciplinary collaborative research penetrating to the conversion of biomass and sustainable raw materials, antimicrobial polymer materials, chemistry/materials for 3D printing, Chinse medicine modifications, and agricultural chemicals (antivirus and antibacterial agents for agriculture use); (6) Research efforts toward scale up and manufacturing.
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Reference: J. Am. Chem. Soc. 2015, 137, 2416-2419; .Nature Commun. 2015, 6, DOI: 10.1038/ncomms7207; Nature? Commun. 2014, 5, doi:10.1038/ncomms4982; J. Am. Chem. Soc. 2013, 135, 8113-8116; Nature Chem. 2013, 5, 835-839.
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Curriculum vitae: 2012- 貴州大學(xué)特聘教授，then 千人計劃/長江學(xué)者特聘教授，貴州大學(xué)“千人計劃”平臺負責人；2009- Assistant then Associate Professor, guest appointment as Singapore NRF Investigator (Nanyang Technological University). 2007-2009 postdoc (UC-Berkeley); 2002-2007 PhD (UW-Madison), 1998-2002 undergraduate (Tsinghua and HKBU),
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Recognitions: 教育部長江學(xué)者，科技部中青年科技創(chuàng)新領(lǐng)軍人才，中組部青年千人計劃，GSK Award on Sustainable Pharmaceutical Manufacturing, Singapore Yong Scientist Award, Singapore NRF Investigator, NRF Fellow, Nanyang Research Award, Thieme Chemistry Journal Award
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