【14th.June】Organocatalytic Radical Methods for Aldehyde Synthesis
日期：2017-06-14
閱讀：1057
TOPIC:Organocatalytic Radical Methods for Aldehyde Synthesis
SPEAKER:王衛(wèi)教授，美國新墨西哥大學終身正教授、華東理工大學藥學院腫瘤藥物研究所所長、中組部首批“千人計劃”特聘專家
TIME:June 14 (Wednesday)15:30pm
LOCATION:化學A樓 528演講廳
INVITER:張萬斌 教授
?
報告簡介：Arguably, aromatic aldehydes are the most fundamentally important substances used in organic synthesis. Therefore, the availability of predictable and chemoselective methods for aldehyde synthesis has a profound impact on chemical synthesis. Classical approaches to aromatic aldehydes are not atom- and step-economical. The state-of-the-art methods for the synthesis of aldehydes rely on transition metal catalyzed (hydro)formylation reactions. Achieving truly practical processes will streamline aldehyde synthesis, but require a fundamentally distinct design paradigm. Toward this end, recently our research laboratories initiated a program aimed at developing sustainable, environmentally friendly, and mild strategies for aldehyde synthesis. In this context, new formylation reagents are designed and new reactivities are harnessed for developing unprecedented organocatalytic photoredox processes for efficient synthesis of structurally diverse aliphatic aldehydes, (hetero)aromatic aldehydes, and α, β-unsaturated aldehydes from feedstock chemicals.
?
http://chemistry.unm.edu/database/personnel/faculty/wei_wang/image.jpg報告人簡介：現(xiàn)任美國新墨西哥大學（University of New Mexico）化學系終身正教授、博士生導師；華東理工大學藥學院腫瘤藥物研究所所長，教授、博士生導師；中組部首批“千人計劃”特聘專家。1988取得南京師范大學化學系理學學士；1993取得中國科學院上海藥物研究所理學碩士；2000獲得美國北卡州立大學（North Carolina State University）化學系化學博士；2000-2001，美國亞利桑那大學（University of Arizona）化學系博士后。社會兼職有《中國藥學學報》和《中國化學快報》編委，中美化學與化學生物學教授協(xié)會（CAPA）主席，《Current Organic Synthesis》和《Letters in Organic Chemistry》編委，以及《Organic Chemistry Insights》榮譽編委等。獲獎及榮譽稱號包括：美國新墨西哥大學的Nominated for the 2006-2007 Outstanding Teacher of the Year Award和The Creative Award 2012，中美化學與化學生物學教授協(xié)會的Distinguished Junior Faculty Award 2008，美國多肽協(xié)會（the American Peptide Society）的The Bruce W. Erickson Young Investigator Award，以及雜志《Tetrahedron Letters》的Most Cited Paper 2004-2007 Award和Most Cited Paper 2006-2009 Award等。王衛(wèi)教授主要研究包括有機合成新方法學的開發(fā)，不對稱催化和綠色化學有機反應(yīng)的研究和新藥研發(fā)。迄今為止，在Nature Commun., Nature Mol. Biol., J. Am. Chem. Soc., Angew. Chem., J. Biol. Chem., Chem. Sci., Org. Lett., Chem. Commun., J. Org. Chem., Chem. Eur. J., Adv. Syn. Catal., ACS Catal., J. Mater. Chem. ChemCatChem 等雜志上發(fā)表論文220多篇，專著1本和章節(jié)16篇，H-index為60，國內(nèi)外專利6件，是化學領(lǐng)域引用率前5%的作者。開發(fā)的手性吡喏烷磺酰胺類催化劑已成功地轉(zhuǎn)讓給美國Aldrich Chemical公司，研發(fā)的新型抗癌藥物轉(zhuǎn)讓給美國Andaman Therapeutics，正開展臨床試驗，可望成為用于治療乳腺癌、肺癌、白血病和前列腺癌的抗癌新藥。
