【18th.Sept.】Exploiting Oxetanes for the Synthesis of Chiral Building Blocks and Medium Rings
日期：2018-09-18
閱讀：1347
題目：Exploiting Oxetanes for the Synthesis of Chiral Building Blocks and Medium Rings
報告人：孫建偉 教授 香港科技大學
時間：2018年9月18日（周二）下午3:00
地點：化學A樓528報告廳
邀請人：張書宇 特別研究員
報告人簡介：
? ?孫建偉教授，2004年畢業(yè)于南京大學，獲得碩士學位，隨后在美國芝加哥大學（The University of Chicago）攻讀博士學位。2008年，進入麻省理工學院(MIT) Gregory C. Fu小組進行博士后研究。2010年，進入香港科技大學。2015年起擔任副教授。獲得的獎項包括Thieme Chemistry Journal Award（Thieme化學期刊獎）、多次獲得Asian Core Program Lectureship Award（亞洲核心計劃報告獎）。目前的研究領(lǐng)域主要集中在有機合成中的不對稱催化。近年來，在Chem. Rev.，J. Am. Chem. Soc., Angew. Chem., Int. Ed.等期刊發(fā)表文章40余篇。
報告摘要：
While epoxides have been well utilized in organic synthesis, their four-membered ring homologues, oxetanes, have been much less exploited.?
Due to the lower ring strain, the reactivity of oxetanes has been less established.?
In particular, catalytic asymmetric opening of the prochiral 3-substitued oxetanes have remained challenging due to difficult remote stereocontrol and the reduced ring-opening propensity.?
Nevertheless, enabled by chiral Br?nsted acid catalysis, our laboratory has developed a series of highly enantioselective intermolecular and intramolecular ring-opening processes of oxetanes, leading to the efficient synthesis of a range of chiral building blocks.?
Moreover, with proper design, oxetanes have also been utilized as either substrates or intermediates in a number of new processes for the synthesis of medium lactones. The reaction details, including mechanisms and scope, will be presented.
