【學(xué)術(shù)報(bào)告】Oxygen?Driven?Fragment?Coupling?for?the?Synthesis?of?Natural?Products?and?Antibacterials
日期：2023-10-18
閱讀：1251
主 題 : Oxygen Driven Fragment Coupling for the Synthesis of Natural Products and Antibacterials
報(bào)告人: Prof. Marisa Kozlowski, University of Pennsylvania, Editor-In-Chief of Organic Letters
時(shí) 間 : 2023年10月18日(周三) 10: 00-12: 00
地 點(diǎn) : 霞光樓200號(hào)報(bào)告廳
邀請(qǐng)人：張萬斌 教授
個(gè)人簡(jiǎn)介
Marisa?Kozlowski?received?an?A.?B.?in?Chemistry?from?Cornell?University?and?a?Ph.D.?from?the?University?of?California?at?Berkeley?for?work?on?the?rational?design?of?enzyme?inhibitors?under?the?direction?of?Paul?Bartlett.?After?studying?asymmetric?catalysis?in?the?laboratories?of?David?A.?Evans?at?Harvard?University?as?a?National?Science?Foundation?postdoctoral?fellow,?she?joined?the?faculty?at?the?University?of?Pennsylvania?and?currently?holds?the?rank?of?Professor?of?Chemistry.?The?major?focus?of?Professor?Kozlowski's?research?is?the?development?of?new?catalytic?methods?for?efficient?organic?synthesis?using?computation?and?high?throughout?screening.?Professor?Kozlowski's?contributions?have?been?recognized?by?a?DuPont?Young?Investigator?Award,?an?NSF?CAREER?Award,?an?Alfred?P.?Sloan?Research?Fellowship,?the?Kahn?Award?for?Distinguished?Teaching?at?the?University?of?Pennsylvania,?an?American?Cancer?Society?Beginning?Research?Scholar?Award,?the?Philadelphia?Organic?Chemists’?Club?Award?in?2010,?election?as?a?Fellow?of?the?American?Association?for?the?Advancement?of?Science?in?2012,?the?Philadelphia?ACS?Section?Award?in?2012,?election?as?an?American?Chemical?Society?Fellow?in?2013,?the?Charles?Ludwig?Distinguished?Teaching?Award?in?2020,?the?Dennis?DeTurck?Award?for?Innovation?in?Teaching?in?2021,?an?ACS?Cope?Scholar?Award?in?2022,?the?Provost’s?Award?for?PhD?Teaching?and?Mentoring,?and?the?Leete?Award?in?2023.?In?addition?to?over?180?independent?publications,?Professor?Kozlowski?coauthored?with?Professor?Patrick?Walsh?the?book?“Fundamentals?of?Asymmetric?Catalysis",?available?from?University?Science?Books.??She?has?served?in?several?leadership?roles?for?the?Organic?Division?of?the?American?Chemical?Society?and?on?numerous?study?sections?including?a?term?as?Chair?of?the?American?Cancer?Society?CDD?Study?Section.??She?is?currently?Editor-In-Chief?of?Organic?Letters.
報(bào)告摘要
Nature?uses?oxidative?couplings?to?construct?carbon-carbon,?carbon-oxygen,?and?carbon-nitrogen?bonds?with?a?high?degree?of?efficiency.?Surprisingly,?few?laboratory?equivalents?are?as?selective?or?as?efficient?as?the?biological?versions.?The?use?of?parallel?microscale?screening?to?discover?selective?and?efficient?catalysts?for?such?processes?using?oxygen?as?the?terminal?oxidant?will?be?discussed.??The?unexpected?outcomes?obtained?highlight?the?value?of?interrogating?large?numbers?of?rationally?selected?variables?under?the?umbrella?of?general?hypothesis.?The?development?of?selective?oxidative?catalytic?processes?for?phenol?coupling,?enol?coupling,?and?alkyl?C–H?activation?will?be?discussed.?Applications?in?total?synthesis?of?hypocrellin,?honokiol,?chaetoglobin,?and?pyrolaside?B?will?be?presented.?Finally,?studies?on?the?mechanisms?of?these?transformations?will?be?described?with?the?goal?of?understanding?the?governing?principles?and?how?they?might?be?used?to?discover?further?new?transformations.
