【學術(shù)報告】Photoenzymatic Catalysis – Using Light to Reveal New Enzyme Functions
日期：2023-10-27
閱讀：2272
主題：Photoenzymatic Catalysis – Using Light to Reveal New Enzyme Functions
報告人： Prof. Todd Hyster, Princeton University
時間：2023年10月27日（周五）15：00-16:00
地點：霞光樓200報告廳
邀請人：葉俊濤 副教授
嘉賓介紹
Todd?Hyster?is?a?Professor?of?Chemistry?at?Princeton?University.?He?received?his?B.S.?in?Chemistry?from?the?University?of?Minnesota.?He?did?his?Ph.D.?studies?with?Tomislav?Rovis?at?Colorado?State?University.?As?part?of?his?Ph.D.,?he?was?a?Marie?Curie?Fellow?with?Thomas?Ward?at?the?University?of?Basel.?He?was?an?NIH?Postdoctoral?Fellow?with?Prof.?Frances?Arnold?at?Caltech.?He?started?his?independent?career?at?Princeton?University?in?2015.?He?joined?the?faculty?at?Cornell?from?2021-2023?before?returning?to?Princeton.?His?group?is?focused?on?developing?new?activation?modes?for?enzymes.?He?has?received?many?awards,?including?Arthur?C.?Cope?Early?Career?Scholar?Award?(2022),?Amgen?Young?Investigator?Award?(2021),?Junior?BIOTRANs?Award?(2021),?Eli?Lilly?Grantee?Award?(2021),?NSF?CAREER?Award?(2019).
報告摘要
Enzymes?are?exquisite?catalysts?for?chemical?synthesis,?capable?of?providing?unparalleled?levels?of?chemo-,?regio-,?diastereo-?and?enantioselectivity.?Unfortunately,?biocatalysts?are?often?limited?to?the?reactivity?patterns?found?in?nature.?In?this?talk,?I?will?share?my?groups?efforts?to?use?light?to?expand?the?reactivity?profile?of?enzymes.?In?our?studies,?we?have?exploited?the?photoexcited?state?of?common?biological?cofactors,?such?as?NADH?and?FMN?to?facilitate?electron?transfer?to?substrates?bound?within?enzyme?active?sites.?In?other?studies,?we?found?that?enzymes?will?electronically?activate?bound?substrates?for?electron?transfer.?In?the?presence?of?common?photoredox?catalysts,?this?activation?can?be?used?to?direct?radical?formation?to?enzyme?active?sites.?Using?these?approaches,?we?can?develop?biocatalysts?to?solve?long-standing?selectivity?challenges?in?chemical?synthesis.
