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2005年9月-2009年6月：武漢大學(xué)，藥學(xué)院，藥學(xué)，學(xué)士
2010年9月-2012年6月：武漢大學(xué)，藥學(xué)院，藥物化學(xué)，碩士 （導(dǎo)師：洪學(xué)傳  教授）
2012年9月-2016年11月：華東師范大學(xué)，化學(xué)與分子工程學(xué)院，有機(jī)化學(xué)，博士 （導(dǎo)師：張俊良  教授）

2017年3月-2017年5月：上海潤(rùn)諾生物科技有限公司，有機(jī)合成高級(jí)研究員
2017年6月-2021年3月：湖南科技學(xué)院，制藥工程系，講師
2021年4月至今：上海交通大學(xué)化學(xué)化工學(xué)院，助理研究員

核苷（酸）的化學(xué)修飾與應(yīng)用

1．湖南省自然科學(xué)基金青年基金，2018JJ3195，已結(jié)題

2．國(guó)家自然科學(xué)基金青年基金，21801075，已結(jié)題

3．上海交通大學(xué)醫(yī)工交叉研究基金，YG2022QN019，在研

(17)  Yangyan Li,*Madiha Butt, Wenhu Bao, Ruoqian Xie, Gang Chen,* Progress in the Functionalization of Purines and Purine Nucleosides by Minisci Reactions Over the Past 50 Years. ChemCatChem 2024, https://doi.org/10.1002/cctc.202401550.

(16) Yangyan Li,? Yutong Zhou,? Dazhi Zhou,? Yujie Jiang, Madiha Butt, Hui Yang, Yingchuan Que, Zhiming Li,* Gang Chen,* Regioselective Homolytic C²–H Borylation of Unprotected Adenosine and Adenine Derivatives via Minisci Reaction. J. Am. Chem. Soc. 2024, 146, 21428.

(15) Ruoqian Xie, Wanlu Li, Yuhua Ge*, Yutong Zhou, Guolan Xiao, Qin Zhao, Yunxi Han, Yangyan Li, Gang Chen*, Late-stage guanine C8–H alkylation of nucleosides, nucleotides, and oligonucleotides via photo-mediated Minisci reaction. Nat. Commun. 2024, 15, 2549.

(14) Yuhua Ge*, Yijiang Peng, Ruoqian Xie, Yang Luo, Yangyan Li*, Gang Chen*, Visible Light-mediated Late-stage Thioetherification of Mercaptopurine Derivatives. Chem. Eur. J., 2024, 30, e202401774.

(13)  Qin Zhao, Ruoqian Xie, Yuxiao Zeng, Wanlu Li, Guolan Xiao, Yangyan Li*, Gang Chen*, Palladium-catalyzed C–H Olefination of Uridine, Deoxyuridine, Uridine Monophosphate and Uridine Analogues, RSC Adv., 2022, 12, 24930. 

(12) Yuhua Ge*, Xingyue Chen, Yi Dong, Hua-Nan Wang, Yangyan Li, Gang Chen*, Access to benzene-modified 2^nd generation strigolactams and GR24 by merging C-H olefination with decarboxylative Giese cyclization, Org. Biomol. Chem., 2021, 19, 7141. 

(11) Yangyan Li#, Le Tu#, Xin Ma, Huan Chen, Yifan Fan, Qiang Zhou, Yao Sun*, Engineering a Smart Nanofluidic Sensor for High-performance Peroxynitrite Sensing Through a Spirocyclic Ring Open/Close Reaction Strategy, ACS Sens., 2021, 6, 3, 808.

(10)  Qingying Ouyang, Le Tu, Yi Zhang, Huan Chen, Yifan Fan, Yingfeng Tu*, Yangyan Li*, and Yao Sun*, Construction of a Smart Nanofluidic Sensor through a Redox Reaction Strategy for High-Performance Carbon Monoxide Sensing, Anal. Chem., 2020, 92, 14947. 

(9)  Xinsheng Xiao*, Sanping Huang, Shanshan Tang, Guokai Jia, Guangchuan Ou and Yangyan Li*, Ligand-free, Quinoline N-assisted Copper-catalyzed Nitrene Transfer Reaction to Synthesize 8-quinolylsulfimides, J. Org. Chem., 2019, 84, 7618.

(8)  Qingwen Gui, Kang Han, Zhuoliang Liu, Zhaohong Su, Xiaoli He, Hongmei Jiang*, Bufan Tian and Yangyan Li*, E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes, Org. Biomol. Chem., 2018, 16, 5748. 

(7) Yangyan Li, Xiang Chen, Xiaoming Chen and Xiao Shen*, Organophosphine-Catalyzed [4C+X] Annulations, Molecules, 2018, 23, 3022. 

(6) Yangyan Li, Chao-Ze Zhu, Junliang Zhang*, Gold-Catalyzed [4+3] Cycloaddition/C–H Functionalization Cascade: Regio- and Diastereoselective Route to Cyclohepta[b]indoles. Eur. J. Org. Chem., 2017, 6609. 

(5) Yangyan Li, WenboLi, Junliang Zhang*, Gold-Catalyzed Enantioselective Annulations. Chem. Eur. J., 2017, 23, 467.

(4) Yangyan Li, Xiao Su, Wei Zhou, Wenbo Li, Junliang Zhang*, Amino Acid Derived Phosphine-Catalyzed Enantioselective 1,4-Dipolar Spiroannulation of Cyclobutenones and Isatylidenemalononitrile. Chem. Eur. J., 2015, 21, 4224.  

(3) Xiao Su#, Wei Zhou#, Yangyan Li, Junliang Zhang*, Design, Synthesis, and Application of a Chiral Sulfinamide Phosphine Catalyst for the Enantioselective Intramolecular Rauhut-Currier Reaction. Angew. Chem. Int. Ed., 2015, 54, 6874.

(2) Maomao He, Chunrong Qu, Bingbing Ding, Hao Chen, Yangyan Li, Guofu Qiu, Xianming Hu, Xuechuan Hong*, Total Synthesis of (±)-8-Oxo-erythrinine, (±)-8-Oxo-erythraline, and (±)-Clivonine, Eur. J. Org. Chem., 2015, 15, 3240. 

(1) Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong*, Zixin Deng, Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters. Green Chem., 2011, 13, 2723.

(5) 陳剛，葛裕華，李婉露，趙芹，謝若芊，李楊燕，肖國(guó)蘭. 一種烷基化核苷、核苷酸、寡核苷酸及其類似物的制備方法[P]. 中國(guó)專利：CN117343119A。

(4) 肖新生，李楊燕，龔紹峰，謝建偉，胡姣. 一種芳并二氫吡咯[2,3]并環(huán)丁烷類化合物及其合成方法[P]. 中國(guó)專利：CN114634443A。

(3) 唐珊珊，肖新生，李楊燕. 一種催化轉(zhuǎn)移氫化硝基環(huán)己烷制備環(huán)己酮肟的方法[P]. 中國(guó)專利：CN109160887A。

(2)  肖新生，李楊燕，歐光川，唐珊珊，劉芳，權(quán)婷，黃三萍. S-烷基-S-喹啉基-N-磺酰基氮硫葉立德化合物及其制備和應(yīng)用[P]. 中國(guó)專利：CN109810056A。

(1) 張俊良，宿曉，周偉，李楊燕. 一種手性叔膦化合物及其全構(gòu)型、制備方法和應(yīng)用[P]. 中國(guó)專利：CN104817591A。