沈建磊長聘（教軌）副教授
電子郵件：[email protected]
通訊地址：上海市東川路800號(hào)轉(zhuǎn)化醫(yī)學(xué)中心
-
教育背景
2013-2016 中國科學(xué)院上海應(yīng)用物理研究所 博士
2010-2013 中國科學(xué)院上海應(yīng)用物理研究所 碩士
2006-2010 合肥工業(yè)大學(xué) 學(xué)士 -
工作經(jīng)歷
2021.08-至今 上海交通大學(xué)化學(xué)化工學(xué)院，長聘教軌副教授
2018.10-2021.07，上海交通大學(xué)化學(xué)化工學(xué)院，長聘教軌助理教授
2016.9-2018.9，華南理工大學(xué)發(fā)光材料與器件國家重點(diǎn)實(shí)驗(yàn)室，博士后 -
研究方向
1、原子精細(xì)發(fā)光團(tuán)簇制備及應(yīng)用
2、生物分析化學(xué)3、細(xì)胞膜成像分析
-
科研項(xiàng)目
上海市青年科技啟明星項(xiàng)目（2021-2024）
上海市科技創(chuàng)新行動(dòng)（2019-2022）
國家自然科學(xué)青年基金（2019-2022）
主持中國博士后基金（I類）（2016-2018）
廣東省自然科學(xué)基金博士啟動(dòng)項(xiàng)目（2017-2020）
廣東省自然科學(xué)基金-自由探索項(xiàng)目（2018-2021）
-
代表性論文專著
2024年
27. Chengpin Liang, Qiuling Huang, Haoran Zheng, Mulin Duan, Xinyi Cheng, Jielin Chen, Qian Li, Zhiyun Zhang*, Chunhai Fan, He Tian, Jianlei Shen*.
Probing Cell Membrane Tension Using DNA Framework-Encoded Vibration-Induced Emission Molecular Assemblies.J. Am. Chem. Soc. 2024, 146, 50, 34341–34351.
26. Cong Li,#, Xiaodong Xie,#, Mingqiang Li, Haozhi Wang, Xinyi Cheng, Jichao Zhang, Qian Li, Jiang Li, Xiaolei Zuo, Chunhai Fan*, J. Shen*.Ultrafast super-resolution imaging exploiting spontaneous blinking of static excimer aggregates. J. Am. Chem. Soc. 2024, 146, 28, 18948–18957.
25. H. Zheng, Y. Zhou, B. Yan, G. Zhou, X. Cheng, S. Lin, M. Duan, J. Li, L. Wang, C. Fan, J. Chen*, and J. Shen*. DNA Framework-Guided Self-Limiting Aggregation for Highly Luminescent Metal Cluster Nanoaggregates. J. Am. Chem. Soc. 2024, 146, 25, 17094–17102.
24. C. Li, J. Chen, T. Man, B. Chen, J. Li, Q. Li, X. Yang, Y. Wan*, C. Fan, J. Shen*.; DNA framework-engineered assembly of cyanine dyes for structural identification of nucleic acids. JACS Au 2024, 4, 3, 1125–1133.
2023年
23. Chen J#, Gu P#, Ran G#, Zhang Y#, Li M, Chen B, Lu H, Han Y, Zhang W, Tang Z, Yan Q, Sun R, Fu X, Chen G, Shi Z, Wang S, Liu X, Li J, Wang L,Zhu Y*, Shen J*, Tang B. Z.*, Fan C.*. Atomically precise photothermal nanomachines. Nature Materials, 2024, 23, 271–280.
Nature Materials期刊 News and Views 發(fā)表題為"Molecular motion cools off gold nanoclusters" 報(bào)道。
22. Li, Y.#; Zheng, H.#; Lu, H.#; Duan, M.; Li, C.; Li, M.; Li, J.; Wang, L.; Li, Q.; Chen, J.*; Shen, J.*; Noncanonical Condensation of Nucleic Acid Chains by Hydrophobic Gold Nanocrystals. JACS Au. 2023. 3, 8, 2206–2215.
21. Zheng, H.#; Li, H.#; Li, M.#; Zhai, T.; Xie, X.; Li, C.; Jing, X.; Liang, C.; Li, Q.; Zuo, X.; Li, J.; Fan, J.*; Shen, J.*; Peng, X.; Fan C.; A Membrane Tension-Responsive Mechanosensitive DNA Nanomachine. Angewandte Chemie-International Edition 2023. 62, e202305896.
2022年
20. Zhai, T.#; Zheng, H.#; Fang, W.#; Gao, Z.; Song, S.; Zuo, X.; Li, Q.; Wang, L.; Li, J.; Shi, J.; Liu, X.; Tian, Y.; Shen, J.*; Fan, C., DNA-Encoded Gold-Gold Wettability for Programmable Plasmonic Engineering. Angewandte Chemie-International Edition 2022. Doi: 10.1002/anie.202210377.
19. Liang, C.; Chen, J.; Li, M.; Ge, Z.; Fan, C.*; Shen, J.*, Probing the self-assembly process of amphiphilic tetrahedral DNA frameworks. Chemical Communications 2022, 58 (60), 8352-8355.
18. Liang, C.; Chen, J.; Li, M.; Li, Q.; Fan, C.*; Luo, S.*; Shen, J.*, Programming the self-assembly of amphiphilic DNA frameworks for sequential boolean logic functions. Chemical Communications 2022, 58 (63), 8786-8789.
17. Li, Y.; Zhai, T.; Chen, J.; Shi, J.; Wang, L.; Shen, J.*; Liu, X.*, Water-Dispersible Gold Nanoclusters: Synthesis Strategies, Optical Properties, and Biological Applications. Chemistry-a European Journal 2022, 28 (10).
16. Li, Y.; Lu, H.; Qu, Z.; Li, M.; Zheng, H.; Gu, P.; Shi, J.; Li, J.; Li, Q.; Wang, L.; Chen, J.; Fan, C.; Shen, J.*, Phase transferring luminescent gold nanoclusters via single-stranded DNA. Science China-Chemistry 2022, 65 (6), 1212-1220.
15. Zhai, T.; Sun, C.; Ye, D.; Xia, K.; Liu, X.; Fan, C.; Li, Q.*; Shen, J.*, Electrochemically driven assembly of framework nucleic acids. Journal of Electroanalytical Chemistry 2022, 905.
14. Feng, L.; Li, C.; Wang, L.; Li, J.; Liu, X.; Li, Q.; Luo, S.*; Shen, J.*, Self-Referenced Surface-Enhanced Raman Scattering Nanosubstrate for the Quantitative Detection of Neurotransmitters. ACS Applied Bio Materials 2022, 5 (5), 2403-2410.
13. Shen, J.; Situ, B.; Du, X.; Wang, Z.; Hu, R.; Li, B.; Qin, A.; Tang, B. Z., Aggregation-Induced Emission Luminogen-Based Dual-Mode Enzyme-Linked Immunosorbent Assay for Ultrasensitive Detection of Cancer Biomarkers in a Broad Concentration Range. ACS Sensors 2022, 7 (3), 766-774.
2021年
12. Chen, B.; Huang, Q.; Qu, Z.; Li, C.; Li, Q.; Shi, J.; Fan, C.; Wang, L.; Zuo, X.; Shen, J.*; Li, J.*, Probing Transient DNA Conformation Changes with an Intercalative Fluorescent Excimer. Angewandte Chemie-International Edition 2021, 60 (12), 6624-6630.
11.Feng, L.; Li, J.; Sun, J.; Wang, L.; Fan, C.; Shen, J.*, Recent Advances of DNA Nanostructure-Based Cell Membrane Engineering. Advanced Healthcare Materials 2021, 10 (6).
10. Gu, P.; Chen, B.; Zhai, T.; Li, Q.; Zuo, X.; Wang, L.; Qin, A.; Zhou, Y.*; Shen, J.*, Immunostimulatory AIE Dots for Live-Cell Imaging and Drug Delivery. ACS Applied Materials & Interfaces 2021, 13 (17), 19660-19667.
9. Yang, Y.; Chen, B.; Zhai, T; Feng, L.; Shen, J.*; Wang, L., Recent Progress of Aggregation-induced Emission Molecular Oligomers. Acta Polymerica Sinica 2021, 52 (9), 1100-1117.
2020年
8. Xia, K.#; Shen, J.#; Li, Q.; Fan, C.; Gu, H., Near-Atomic Fabrication with Nucleic Acids. ACS Nano 2020, 14 (2), 1319-1337.
7. Shen, J.; Tao, K.; Gu, P.; Gui, C.; Wang, D.; Tan, Z.; Wang, L.; Wang, Z.; Qin, A.; Tang, B. Z.; Bao, S., Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo. Science China-Chemistry 2020, 63 (3), 393-397.
6. Zhai, T.; Li, Q.; Shen, J.*; Li, J.; Fan, C., DNA nanostructure-encoded fluorescent barcodes. Aggregate 2020, 1 (1), 107-116.
5. Zhang, Y.#; Shen, J.#; Hu, R.; Shi, X.; Hu, X.; He, B.; Qin, A.; Tang, B. Z., Fast surface immobilization of native proteins through catalyst-free amino-yne click bioconjugation. Chemical Science 2020, 11 (15), 3931-3935.
2019年
4. Shen, J.#; Liang, L.#; Xiao, M.#; Xie, X.; Wang, F.; Li, Q.; Ge, Z.; Li, J.; Shi, J.; Wang, L.; Li, L.; Pei, H.; Fan, C., Fractal Nanoplasmonic Labels for Supermultiplex Imaging in Single Cells. JACS. 2019, 141 (30), 11938-11946.
3. Xie, M.; Li, F.; Gu, P.; Wang, F.; Qu, Z.; Li, J.; Wang, L.; Zuo, X.; Zhang, X.*; Shen, J.*, Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment. Cell Proliferation 2019, 52 (4).
2. Shen, J.; Jiang, X.; Xu, L.; Ge, Z.; Li, Q.; Song, B.; Wang, L.; Song, S., Poly-Adenine-Engineered Gold Nanogaps for SERS Nanostructures. ACS Applied Nano Materials 2019, 2 (6), 3501-3509.
1. Shen, J.; Zhang, Y.; Hu, R.; Kwok, R. T. K.; Wang, Z.; Qin, A.; Tang, B. Z., Dual-Mode Ultrasensitive Detection of Nucleic Acids via an Aqueous "Seesaw" Strategy by Combining Aggregation-Induced Emission and Plasmonic Colorimetry. ACS Applied Nano Materials 2019, 2 (1), 163-169.
2018年前
7. Shen, J.; Luan, B.; Pei, H.; Yang, Z.; Zuo, X.; Liu, G.; Shi, J.; Wang, L.; Zhou, R.; Cheng, W.; Fan, C., Humidity-Responsive Single-Nanoparticle-Layer Plasmonic Films. Advanced Materials 2017, 29 (35).
6. Shen, J.; Tang, Q.#; Li, L.#; Li, J.; Zuo, X.; Qu, X.; Pei, H.; Wang, L.; Fan, C., Valence-Engineering of Quantum Dots Using Programmable DNA Scaffolds. Angewandte Chemie-International Edition 2017, 56 (50), 16077-16081.
5. Shen, J.; Xu, L.; Wang, C.; Pei, H.; Tai, R.; Song, S.; Huang, Q.; Fan, C.; Chen, G., Dynamic and Quantitative Control of the DNA-Mediated Growth of Gold Plasmonic Nanostructures. Angewandte Chemie-International Edition 2014, 53 (32), 8338-8342.
4. Hu, C.#; Shen, J.#; Yan, J.; Zhong, J.; Qin, W.; Liu, R.; Aldalbahi, A.; Zuo, X.; Song, S.; Fan, C.; He, D., Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging. Nanoscale 2016, 8 (4), 2090-2096
3. Shen, J.; Su, J.; Yan, J.; Zhao, B.; Wang, D.; Wang, S.; Li, K.; Liu, M.; He, Y.; Mathur, S.; Fan, C.; Song, S., Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification. Nano Research 2015, 8 (3), 731-742.
2. Shen, J.; Hu, R.; Zhou, T.; Wang, Z.; Zhang, Y.; Li, S.; Gui, C.; Jiang, M.; Qin, A.; Tang, B. Z., Fluorescent Sensor Array for Highly Efficient Microbial Lysate Identification through Competitive Interactions. ACS Sensors 2018, 3 (11), 2218-2222.
1. Zhao, B.#; Shen, J.#; Chen, S.; Wang, D.; Li, F.; Mathur, S.; Song, S.; Fan, C., Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules. Chemical Science 2014, 5 (11), 4460-4466.
-
軟件版權(quán)登記及專利
已授權(quán)國內(nèi)發(fā)明專利：
1、一種形狀可定制的框架核酸納米發(fā)光體及其制備方法和應(yīng)用，CN201910589495.9
2、一種熒光傳感陣列對微生物進(jìn)行分型鑒定的方法，CN201810783172.9
3、一種聚集誘導(dǎo)發(fā)光/表面等離子體色度分析雙模式核酸檢測方法，CN201810783689.8
4，一種用于生物分子固定的活化炔修飾表面玻璃材料及表面改性方法，CN201910309301.5
5，一種雙模式ELISA酶免顯色劑及其制備與應(yīng)用，CN201811159246.8
-
榮譽(yù)獎(jiǎng)勵(lì)
上海市青年科技啟明星（2021）
中國科學(xué)院大學(xué)院長獎(jiǎng)（2016）
中國科學(xué)院大學(xué)優(yōu)秀畢業(yè)生（2016）
-
人才需求
長期歡迎具備原子精細(xì)團(tuán)簇合成、超分辨成像背景、細(xì)胞膜化學(xué)研究背景的博士生及博士后加入！
