張書宇教授
電子郵件：[email protected]
通訊地址：上海市東川路800號(hào)上海交通大學(xué)化學(xué)化工學(xué)院B329
個(gè)人主頁(yè)： (EN): http://www.12315jq.cn/en/Faculty_Directory/232.html
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教育背景
1998-2002：蘭州大學(xué)化學(xué)化工學(xué)院，學(xué)士
2005-2010：蘭州大學(xué)化學(xué)化工學(xué)院，博士（導(dǎo)師：涂永強(qiáng)院士）
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工作經(jīng)歷
2002-2010：蘭州大學(xué)功能有機(jī)分子化學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室
2010-2011：美國(guó)芝加哥大學(xué) (The University of Chicago) 化學(xué)系，博士后（導(dǎo)師：何川教授）
2011-2014：美國(guó)賓夕法尼亞州立大學(xué) (Penn State University) 化學(xué)系，博士后（導(dǎo)師：陳弓教授）
2015-2020：上海交通大學(xué)化學(xué)化工學(xué)院，特別研究員（長(zhǎng)聘教軌副教授）
2020-2021：上海交通大學(xué)化學(xué)化工學(xué)院，院長(zhǎng)助理
2021-2022：上海交通大學(xué)化學(xué)化工學(xué)院，長(zhǎng)聘副教授
2022-至今： 上海交通大學(xué)化學(xué)化工學(xué)院，教授，副院長(zhǎng)
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研究方向
以合成化學(xué)為基礎(chǔ)和核心的交叉學(xué)科研究。
1）合成方法學(xué)：C-H活化反應(yīng)、烯基軸手性化學(xué)、電化學(xué)重排反應(yīng)；
2）全合成化學(xué)：以非活潑C-H活化反應(yīng)為核心的天然產(chǎn)物及活性藥物分子的集體全合成；
3）先進(jìn)材料創(chuàng)制：結(jié)合計(jì)算和機(jī)器學(xué)習(xí)的 NIR II 熒光探針，CPL 探針，先進(jìn)PI材料。
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科研項(xiàng)目
感謝國(guó)家自然科學(xué)基金委、科技部重點(diǎn)研發(fā)計(jì)劃、上海市科委、上海市教委、上海交通大學(xué)及海外青年人才項(xiàng)目經(jīng)費(fèi)支持！
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代表性論文專著
近期代表性論文：
1) Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging
Rui-Tian Ge, Feng Xiong, Zhen Bang Chen, Yuanjie Wang, Lin Zheng, Jia Zhou, Di Wu*, Shu-Yu Zhang*
Chem, 2025, 11, 102489.2) Allylic C–H oxygenation of unactivated internal olefins by the Cu/azodiformate catalyst system
Le Wang, Yuan She, Jie Xiao, Zi-Hao Li, Shen-Yuan Zhang, Peng-Fei Lian, Tong-Mei Ding, Shu-Yu Zhang*
Nature Commun. 2025, 16, 875.3) Machine learning for active sites prediction of quinoline derivatives
Jie Sun, Zi-Hao Li, * Yi-Fei Yang, Shu-Yu Zhang*
Artificial Intelligence Chemistry, 2025, 100082.4) Organocatalytic asymmetric tandem reaction for the enantioselective synthesis of chiral oxindoles to construct CyK dyes
Le Wang, Zi-Hao Li, Di Wu, Rui-Tian Ge, Jia Zhou, Yin-Feng Zhang, Shu-Yu Zhang*
Chem Catal. 2025, 5, 101188.5) Organocatalytic Asymmetric Synthesis of Sulfonyl-Substituted Furans via a Cascade 1,6-Addition/Cyclization/Enantioselective Protonation Pathway
Peng-Fei Lian, Zi-Hao Li*, Xin-Yue Qiu, Tong-Mei Ding, Shu-Yu Zhang*
ACS Catal. 2024, 14, 12717.6) Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone
Shi-Qiang Wei, Zi-Hao Li, Shuang-Hu Wang, Hua Chen, Xiao-Yu Wang, Yun-Zhou Gu, Ye Zhang, Hong Wang, Tong-Mei Ding, Shu-Yu Zhang,* Yong-Qiang Tu*
J. Am. Chem. Soc. 2024, 146, 18841.7) Enantioselective sequential Michael addition/C-H olefination/Michael reaction for the efficient collective synthesis of clavine alkaloids
Zhi-Gang Ma,? Yu Hao,? Wei Jiang, Xian-Yu Pan, Tong-Mei Ding, Si-Hua Hou, Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2024, 102112.8) How achiral Br?nsted acid involves in co-catalyst model with chiral phosphoric acid for construction of quaternary carbon stereocenter
Zi-Hao Li,? Jia Zhou,? Chang Liu, Fu-Xin Tan, Le Wang, Guo-Dong Zhu, Shu-Yu Zhang*
Chem Catal. 2024, 4, 100918.9) Cooperative Cu/azodiformate system-catalyzed allylic C–H amination of unactivated internal alkenes directed by aminoquinoline
Le Wang, Cheng-Long Wang, Zi-Hao Li, Peng-Fei Lian, Jun-Chen Kang, Jia Zhou, Yu Hao, Ru-Xin Liu, He-Yuan Bai, Shu-Yu Zhang*
Nature Commun. 2024, 15, 1483.10) Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems
Ai-Fang Wang, Jin-Miao Tian, Xiao-Jing Zhao, Zi-Hao Li, Ye Zhang, Ka Lu, Hong Wang, Shu-Yu Zhang,* Yong-Qiang Tu,* Tong-Mei Ding, Yu-Yang Xie
Angew Chem. Int. Ed. 2023, 62, e202308858.11) Axially Chiral Styrene-Based Organocatalysts and Their Application in Asymmetric Cascade Michael/Cyclization Reaction
Yu Hao, Zi-Hao Li, Zhi-Gang Ma, Ru-Xin Liu, Rui-Tian Ge, Quan-Zhe Li, Tong-Mei Ding, and Shu-Yu Zhang*
Chem. Sci. 2023, 9496.12) Electroreductive fluoroalkylative heteroarylationof unactivated alkenes via an unconventionalremote heteroaryl migration
Chao Chen, Shen-Yuan Zhang, Shuai-Xin Li, Zi-Hao Li, Ru-Xin Liu, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2023, 4, 101385.13) Synthetic strategies and mechanistic studies of axially chiral styrenes
Zi-Hao Li, Quan-Zhe Li, He-Yuan Bai, Shu-Yu Zhang*
Chem Catal. 2023, 3, 100594.14) Bioinspired Palladium-Catalyzed Intramolecular C(sp3)?H Activation for the Collective Synthesis of Proline Natural Products
Quan-Zhe Li,? Si-Hua Hou,? Jun-Chen Kang, Peng-Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong-Mei Ding and Shu-Yu Zhang*
Angew Chem. Int. Ed. 2022, 61, e202207088.15) Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli
Ya Zhang#, Weizhong Chen#, Di Wu#, Yushi Liu, Zhaowei Wu, Jian Li, Shu-Yu Zhang,* and Quanjiang Ji*
Nucleic Acids Research, 2022, 50, 5948.16) CPA-Catalyzed Enantioselective Dearomative Electrophilic Hy-drazination : Access to Chiral Aza-Quaternary Carbon Indolenines
Xin-Yue Qiu, Zi-Hao Li, Jia Zhou, Peng-Fei Lian, Li-Kun Dong, Tong-Mei Ding, He-Yuan Bai, and Shu-Yu Zhang*
ACS Catal. 2022, 12, 7511.17) Ni-Catalyzed, Enantioselective Three-component Radical Relayed Reductive Coupling of Alkynes: Synthesis of Axially Chiral Styrenes
Quan-Zhe Li, Zi-Hao Li, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Chem Catal. 2022, 2, 3185.更多發(fā)表論文請(qǐng)?jiān)L問(wèn)：
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人才培養(yǎng)
祝賀練鵬飛、王樂(lè)同學(xué)順利通過(guò)2024年度博士論文答辯！
祝賀劉汝欣同學(xué)順利通過(guò)2024年度碩士論文答辯，獲評(píng)"上海交大優(yōu)秀畢業(yè)生"！
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學(xué)術(shù)兼職
《上海交通大學(xué)學(xué)報(bào)自然科學(xué)版》青年編委
上海市手性藥物分子工程重點(diǎn)實(shí)驗(yàn)室 副主任
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榮譽(yù)獎(jiǎng)勵(lì)
2023: 全國(guó)大學(xué)生化學(xué)實(shí)驗(yàn)創(chuàng)新大賽華東賽區(qū)一等獎(jiǎng) 指導(dǎo)教師
2023: 上海市化學(xué)化工優(yōu)秀論文一等獎(jiǎng) 指導(dǎo)教師
2022: 國(guó)家教學(xué)成果一等獎(jiǎng)(R6)
2021: 上海交通大學(xué)“教書育人獎(jiǎng)”
2021: Thieme Chemistry Journals Award
2020: 上海交通大學(xué)“優(yōu)異學(xué)士學(xué)位論文(1%)指導(dǎo)教師”
2019: 上海交通大學(xué)“燭光獎(jiǎng)”
2019: 上海交通大學(xué)“優(yōu)秀班主任”
2016: 上海市曙光學(xué)者
2016: 國(guó)家自然科學(xué)二等獎(jiǎng)(R5)
2015: 教育部自然科學(xué)一等獎(jiǎng)(R5)
2015: 中組部青年人才計(jì)劃
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教學(xué)工作
本科生：致遠(yuǎn)學(xué)院《Organometallic Chemistry》
研究生：化學(xué)化工學(xué)院《金屬有機(jī)化學(xué)》、致遠(yuǎn)榮譽(yù)課程《高等有機(jī)化學(xué)》
承擔(dān)本科生：大創(chuàng)項(xiàng)目、致遠(yuǎn)學(xué)者項(xiàng)目、莙政學(xué)者項(xiàng)目。
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教學(xué)成果
代表性教學(xué)學(xué)術(shù)研究：
1) Using Computational Chemistry to Improve Students' Multidimensional Understanding of Complex Electrophilic Aromatic Substitution Reactions: Further Analysis of the Solvent Effect, Temperature Influence, and Kinetic Behaviors
Li-Kun Dong, Zi-Hao Li, Shu-Yu Zhang*
J. Chem. Educ. 2021, 98, 3226-3236.2) Project-Based Learning in Green Electrochemistry for Undergraduates: An Efficient Synthesis Route of Natural Product
Ru-Xin Liu, Feng Xiong, Chao Chen, Tong-Mei Ding, Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 689-696.3) Bringing Green Organic Electrochemistry to Undergraduates: A Designed Comparison Organic Experiment of Bromination
Feng Xiong, Ru-Xin Liu, Xiao-Xuan Fan, Min Zhang, Yuan She, Wei-Qing Cao, Chao Chen, Tong-Mei Ding, and Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 4686-4695.4) Using Computational Chemistry to Compare the Strength of Lewis Bases from HOMO Orbital Energy
Xin-Yu Chen, Zi-Hao Li,* Li-Kun Dong, Xie-Yang Jiang, and Shu-Yu Zhang*
Chin. J. Chem. Educ. 2024, 45, 38-44.5) Stepwise or Concerted Mechanisms? Rethinking of the Classical Carbocation Rearrangement Reaction
Qing-Yun Cai, Hao Zheng, Zi-Hao Li, Li-Kun Dong, Jia Zhou, and Shu-Yu Zhang*
J. Chem. Educ. 2024, 101, 5068-5076. -
人才需求
課題組招生信息：
2025級(jí)，2026級(jí) 博士研究生已招滿，謝謝大家！
課題組開放支持本科生項(xiàng)目，歡迎隨時(shí)聯(lián)系和交流！
博士后長(zhǎng)期招聘，提供可觀薪資，申請(qǐng)人煩請(qǐng)通過(guò)email提供CV聯(lián)系！
