張川研究員
辦公電話：021-54740717
電子郵件：[email protected]
通訊地址：上海市東川路800號(hào)
個(gè)人主頁(yè)： www.zhangresearchgroup.com
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教育背景
1999-2003：清華大學(xué)化學(xué)系，學(xué)士
2003-2006：清華大學(xué)化學(xué)系，碩士
2006-2011：美國(guó)普渡大學(xué)化學(xué)系，博士 -
工作經(jīng)歷
2011-2014：美國(guó)西北大學(xué)化學(xué)系，博士后，導(dǎo)師：Professor Chad A. Mirkin
2014-至今：上海交通大學(xué)化學(xué)化工學(xué)院特別研究員，研究員，特聘教授 -
研究方向
1） 新型核酸藥物、基因遞送和治療
2） 藥物遞送系統(tǒng)、新型生物材料合成和應(yīng)用
3） 核酸納米技術(shù)，生物大分子功能材料及納米生物醫(yī)學(xué)
團(tuán)隊(duì)2024碩士研究生目前尚有名額，歡迎對(duì)上述方向感興趣的同學(xué)報(bào)考！
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科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金杰出青年科學(xué)基金，“核酸藥物遞送系統(tǒng)”，2023/01-2027/12，主持。
2. 國(guó)家自然科學(xué)基金面上項(xiàng)目，“硫代寡核苷酸-藥物偶聯(lián)物的合成、組裝及其應(yīng)用研究”，2020/01-2023/12，主持。
3. 國(guó)家自然科學(xué)基金國(guó)際(地區(qū))合作與交流項(xiàng)目（中港合作基金），“自組裝DNA納米結(jié)構(gòu)高效基因載體的構(gòu)建及其與細(xì)胞的相互作用”，2017/01-2020/12，主持。
4. 國(guó)家自然科學(xué)基金面上項(xiàng)目，“DNA誘導(dǎo)新型納米粒子超晶格材料組裝及其性能研究”，2017/01-2020/12，主持。
5. 國(guó)家重點(diǎn)研發(fā)計(jì)劃課題，“新型高分子眼科功能性植入材料的研發(fā)和應(yīng)用”課題二“眼眶軟組織再生材料的研發(fā)與作用機(jī)制”2018/09-2022/06，課題負(fù)責(zé)人。
6. 國(guó)家重點(diǎn)研發(fā)計(jì)劃課題，“精確自組裝”納米存儲(chǔ)基元的設(shè)計(jì)與合成”課題一“使用合成 DNA 進(jìn)行數(shù)據(jù)存儲(chǔ)的技術(shù)研發(fā)”，2019/07-2024/06，參與。
7. 國(guó)家自然科學(xué)基金重大研究計(jì)劃，“初級(jí)組裝體的模塊化組裝、功能集成與仿生應(yīng)用”，2016/01-2018/12，參與。
8. 國(guó)家自然科學(xué)基金青年基金，“高密度核酸-聚酯膠束親和雜化遞送基因藥物研究”，2016/01-2018/12，主持。
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代表性論文專(zhuān)著
At SJTU (Selected)
14) Fujun Wang, Miao Xie, Yangyang Huang, Yuhe Liu, Xinlong Liu, Lijuan Zhu, Xinyuan Zhu, Yuanyuan Guo*, and Chuan Zhang*, "In Situ Vaccination with An Injectable Nucleic Acid Hydrogel for Synergistic Cancer Immunotherapy", Angew. Chem. Int. Ed., 2024, 63, e202315282.
13) Yuanyuan Guo, Qiushuang Zhang, Qiwen Zhu, Jing Gao, Xinyuan Zhu, Haijun Yu,* Yuehua Li,* Chuan Zhang*, “Co-packaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy”, Sci. Adv., 2022, 8, eabn2941.
12) Lijuan Zhu, Jiapei Yang, Yuan Ma, Xinyuan Zhu, Chuan Zhang*, “Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy”, J. Am. Chem. Soc., 2022, 144, 1493-1497.
11) Yuhe Liu, Jiao Zhang, Yuanyuan Guo, Ping Wang, Yue Su, Xin Jin, Xinyuan Zhu, Chuan Zhang*, “Drug-Grafted DNA as A Novel Chemogene for Targeted Combinatorial Cancer Therapy”, Exploration, 2022, 2, 20210172.
10) Xihui Gao, Sha Li, Fei Ding, Xinlong Liu, Yijing Wu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Virus-Mimicking Nucleic Acid Nanogel Reprograms the Microglia and Macrophage for Glioblastoma Therapy”, Adv. Mater., 2021, 33, 2006116.
9) Lijuan Zhu, Yuanyuan Guo, Qiuhui Qian, Deyue Yan, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer”, Angew. Chem. Int. Ed., 2020, 59, 17944-17950.
8) Huan Ge, Dongya Wang, Yue Pan, Yuanyuan Guo, Hongyu Li, Fan Zhang, Xinyuan Zhu, Yuehua Li, Chuan Zhang*, Ling Huang*, “Sequence-Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies”, Angew. Chem. Int. Ed., 2020, 59, 8133-8137.
7) Jiao Zhang, Yuanyuan Guo, Fei Ding, Gaifang Pan, Xinyuan Zhu, and Chuan Zhang*, “A Camptothecin-Grafted DNA Tetrahedron as Precise Nanomedicine to Inhibit the Tumor Growth”, Angew. Chem. Int. Ed., 2019, 58, 13794-13798.
6) Xihui Gao, Sha Li, Fei Ding, Hongjia Fan, Leilei Shi, Lijuan Zhu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Rapid Detection of Exosomal microRNAs Using Virus-Mimicking Fusogenic Vesicles”, Angew. Chem. Int. Ed., 2019, 58, 8719-8723.
5) Quanbing Mou, Yuan Ma, Fei Ding, Xihui Gao, Deyue Yan, Xinyuan Zhu, and Chuan Zhang*, “Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides to Reverse Chemoresistance”, J. Am. Chem. Soc., 2019, 141, 6955-6966.
4) Yuanyuan Guo, Jiao Zhang, Fei Ding, Gaifang Pan, Jing Li, Jing Feng, Xinyuan Zhu, and Chuan Zhang*, “Stressing the Role of DNA as Drug Carrier: Synthesis of the DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides”, Advanced Materials, 2019, 31, 1807533.
3) Ding F., Mou Q., Ma Y., Pan G., Guo Y., Tong G., Choi C. H. J., Zhu X., Zhang C.*, “Crosslinked Nucleic Acid Nanogel For Effective siRNA Delivery and Antitumor Therapy”, Angew. Chem. Int. Ed., 2018, 57, 3064-3068.
2) Mou Q., Ma Y., Pan G., Xue B., Yan D., Zhang C.*, Zhu X.*, “DNA Trojan Horses: The Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy”, Angew. Chem. Int. Ed., 2017, 56, 12528–12532.
1) Wang D., Liu B., Ma Y., Wu C., Mou Q., Deng H., Wang R., Yan D., Zhang C.*, Zhu X.*, “A molecular recognition approach to synthesize nucleoside analogue based multifunctional nanoparticles for targeted cancer therapy”, J. Am. Chem. Soc., 2017, 139, 14021-14024.
Before SJTU (Selected)
1) Zhang C., Li X., Tian C., Li. Y., Jiang W., Mao C.D.*, “DNA Nanocages Swallow Gold Nanoparticles (AuNPs) to Form AuNP@DNA Cage Core-Shell Structures”, ACS Nano 8, 1130-1135 (2014).
2) Zhang C., Macfarlane R. J., Young K. L., Choi C. H. J., Hao L., Auyeung E., Liu G., Zhou X., Mirkin C. A.,* “A General Approach to DNA-Programmable Atom Equivalents”, Nat. Mater., 12, 741-746 (2013).
Also see: Simon U. “Nanoparticle self-assembly: Bonding them all”. Nat. Mater. 12, 694 (2013).Highlighted by C&EN, 21, 41 (2013).
3) Zhang C., Tian C., Li X., Qian H., Hao C., Wang G., Jiang W., Mao C.D.*, “Reversibly Switching the Surface Porosity of a DNA Tetrahedron”, J. Am. Chem. Soc., 134, 11998-12001 (2012).
4) Zhang C., Wu W.M., Li X., Tian C., Qian H., Wang G., Jiang W., Mao C.D.*, “Controlling the Chirality of DNA Nanocages”, Angew. Chem. Int. Ed., 51, 7999-8002 (2012).
5) Zhang C., Tian C., Guo F., Liu Z., Jiang W., Mao C.D.*, “DNA-Directed Three Dimensional (3D) Protein Organization”, Angew. Chem. Int. Ed., 51, 3382-3385 (2012).
6) Zhang C., He Y., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D.*, “Exterior modification of a DNA tetrahedron”, Chem Comm., 46, 6792-6794 (2010).
7) Zhang C., Ko S. H., Su M., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D.*, “Symmetry Controls the Face Geometry of DNA Polyhedra”, J. Am. Chem. Soc., 131: 1413-1415 (2009).
8) Zhang C., He Y., Mao C.D.*, “A Brief Review: DNA Nanocages Self-assembled by Star-shaped DNA Motifs”, Faraday Discuss., 143, 221-233 (2009).
9) Zhang C., Mao C.D.*, “DNA Nanotechnology: Bacteria as factories”, Nat. Nanotech., 3: 707-708 (2008).
10) Zhang C., Su M., He Y., Zhao X., Fang P.A., Ribbe A.E., Jiang W., Mao C.D.*; “Conformational Flexibility Facilitates Self-Assembly of Complex DNA Nanostructures”, Proc. Natl. Acad. Sci. USA, 105: 10665-10669 (2008).
11) He Y., Ye T., Su M., Zhang C., Ribbe A.E., Jiang W., Mao C.D.*, “Hierarchical Self-assembly of DNA into Symmetric SupramolecularPolyhedra”, Nature, 452: 198-201 (2008).
12) Zhang C., He Y., Chen Y., Ribbe A.E., Mao C.D.*; “Aligning One-dimensional DNA Duplexes into Two-dimensional Crystals” J. Am. Chem. Soc., 129: 14134-14135 (2007).
13) Zhang C., Zhu Y.F.*, “Synthesis of Square Bi2WO6Nanoplates as High Activity Visible-Light-Driven Photocatalysts”, Chem. Mater., 17: 3537-3545 (2005).
14) Zhang C., Wang L., Cui L.P., Zhu Y.F.*, “A Novel Method for The Synthesis of Nano-sized BaAl2O4 with Thermal Stability”, J. Cryst. Growth., 255: 317-323 (2003). -
學(xué)術(shù)兼職
2023 – 至今 Biomaterials Science副主編
2023 – 至今 Smart Molecules青年編委
2019 – 至今 《高等化學(xué)學(xué)報(bào)》青年編委
2018 – 至今 中國(guó)醫(yī)藥生物技術(shù)協(xié)會(huì)納米生物技術(shù)分會(huì)委員會(huì)委員
2018 – 至今 中國(guó)醫(yī)藥衛(wèi)生事業(yè)發(fā)展基金會(huì)干眼防治專(zhuān)家委員會(huì)委員
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榮譽(yù)獎(jiǎng)勵(lì)
1) 2022 國(guó)家杰青
2） 2014“求是青年學(xué)者”獎(jiǎng)
3） M.G. Mellon Award （2010）
4） Bisland Fellowship (2009) -
人才需求
長(zhǎng)期招收博士生、博士后及助理研究員！
團(tuán)隊(duì)2024碩士研究生目前尚有名額，歡迎對(duì)生物醫(yī)藥、核酸藥物以及生物醫(yī)用高分子材料感興趣的同學(xué)報(bào)考！
