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2004.08-2009.09     紐約大學(xué)，化學(xué)，博士，導(dǎo)師: Ned Seeman院士

1999.09-2004.07     中國科學(xué)技術(shù)大學(xué)，應(yīng)用化學(xué)，學(xué)士，導(dǎo)師: 錢逸泰院士

2022.01-                  上海交通大學(xué)-化學(xué)化工學(xué)院/轉(zhuǎn)化醫(yī)學(xué)院，研究員

2015.06-2021.12     復(fù)旦大學(xué)-生物醫(yī)學(xué)研究院，研究員

2009.11-2015.05     耶魯大學(xué)，分子生物學(xué)，博士后，導(dǎo)師: Ronald Breaker院士

擅長核酸編輯和組裝，致力于開拓DNA在納米材料、生物傳感、臨床診斷等方面的基礎(chǔ)和應(yīng)用研究，開展的方向包括：

• 對靶點或標(biāo)志物明確的重大惡性腫瘤和慢性疾病，開發(fā)可用于體液診斷的便捷適配體探針（試劑盒）；對于標(biāo)志物未知的重大惡性腫瘤和慢性疾?。ㄖ饕侨幮匀橄侔?，以適配體探針庫為抓手，通過臨床樣本間的對沖抵消，篩選鑒定疾病相關(guān)的標(biāo)志物和對應(yīng)的檢測探針，揭示疾病的分子機(jī)制并明確藥物可作用的靶點；

• 開發(fā)新型3D框架核酸的設(shè)計和組裝方案，在保持組裝體近原子分辨率的前提下，將自組裝的尺度在3D空間從納米推向微米和亞毫米級，以滿足其作為介質(zhì)在材料科學(xué)中的更多應(yīng)用需求；同時開發(fā)活細(xì)胞生產(chǎn)制備框架核酸的生物技術(shù)，降低制備成本，為框架核酸的臨床研究提供支持；

• 利用試管內(nèi)進(jìn)化的高效篩選策略分離獲得重大疾病相關(guān)的核酸酶（DNAzyme和Ribozyme），將其與框架核酸融合，編輯組裝“環(huán)境響應(yīng)型智能納米藥物載體”，用于重大疾病的靶向精確遞藥。
  

• 國自然基金委創(chuàng)新研究群體 “腫瘤免疫治療新策略”

      項目編號：82121002，  2022-2026  骨干 主持  200萬

• 科技部重點研發(fā)計劃 “微納生物機(jī)器人的定向合成和診療應(yīng)用”（課題一）

      課題編號：2020YFA0908901，  2020-2025  主持  604萬

• 國自然基金委重大研究計劃 “腫瘤演進(jìn)與診療的分子功能可視化研究”（培育項目）

      項目編號：91859104，  2019-2021  主持  60萬

• 江蘇貝格爾生物醫(yī)藥有限公司 橫向合作課題“外泌體捕捉與生物標(biāo)記物檢測開發(fā)”

      2019-2020  主持  30萬

• 國自然國際（地區(qū)）合作與交流重大項目“靶向治療類風(fēng)濕性關(guān)節(jié)炎的核酸納米抗體研究”

      項目編號：81861138004，  2018-2020  共同主持  總經(jīng)費300萬，個人承擔(dān)150萬

• 國自然面上項目 “DNA納米骨架的組裝及其在生物和材料學(xué)中的應(yīng)用”

      項目編號：21673050，  2017-2020  主持  已結(jié)題  68萬

• 科技部國家重點研發(fā)計劃“重大慢性非傳染性疾病防控研究”

       項目編號：2016YFC1306400， 2016-2020  子課題負(fù)責(zé)人  45.4萬

• 主持國家級青年人才項目   2015-2018  主持  300萬

代表性文章（獨立PI期間）

• Qinqin Hu^￥; Zongxuan Tong^￥; Ayimukedisi Yalikong^￥; Li-Ping Ge^￥; Qiang Shi; Xinyu Du; Pu Wang; Xi-Yu Liu; Wuqiang Zhan; Xia Gao; Di Sun; Tong Fu; Dan Ye; Chunhai Fan; Jie Liu; Yun-Shi Zhong*; Yi-Zhou Jiang*; Hongzhou Gu*. “DNAzyme-Based Faithful Probing and Pulldown to Identify Candidate Biomarkers of Low Abundance.” Nature Chemistry 2024, 16, 122-131.

• Mo Zhou^￥; Tianbin Xu^￥; Kai Xia; Haiqing Gao; Wei Li; Tingting Zhai; Hongzhou Gu*. “Small DNAs That Specifically and Tightly Bind Transition Metal Ions.” Journal of the American Chemical Society 2023, 145, 16, 8776-8780.

• Xiao Chu; Xinyu Du; Longhua Yang; Ziyi Wang; Yi Zhang; Xiaonan Wang; Lijun Dai; Jiangnan Zhang; Jie Liu; Nan Zhang*; Yongxing Zhao*; Hongzhou Gu*. “Targeting Tumor Necrosis Factor Receptor 1 with Selected Aptamers for Anti-Inflammatory Activity.” ACS Applied Materials & Interfaces 2023, 15, 11599-11608.

• Qiao Zhang^￥; Kai Xia^￥; Meng Jiang^￥; Qingting Li; Weigang Chen; Mingzhe Han; Wei Li; Rongqin Ke; Fei Wang; Yongxing Zhao; Yuehua Liu; Chunhai Fan; Hongzhou Gu*. “Catalytic DNA-Assisted Mass Production of Arbitrary Single-Stranded DNA.” Angewandte Chemie International Edition 2023, e202212011.

• Jin Liu^￥; Liman Chen^￥; Tingting Zhai; Wei Li; Yuehua Liu; Hongzhou Gu*. “Programmable Assembly of Amphiphilic DNA through Controlled Cholesterol Stacking.” Journal of the American Chemical Society 2022, 144, 36, 16598-16603.

• Yang Yang^￥; Zhenyong Wu^￥; Laurie Wang; Kaifeng Zhou; Kai Xia; Qiancheng Xiong; Longfei Liu; Zhao Zhang; Edwin R Chapman; Yong  Xiong; Thomas J Melia; Erdem Karatekin; Hongzhou Gu*; Chenxiang Lin*. “Sorting liposomes of distinct sizes by DNA-brick assisted centrifugation.” Nature Chemistry 2021, 13, 335-342.

• Youli Jia^￥; Liman Chen^￥; Jin Liu; Wei Li; Hongzhou Gu*. “DNA Catalyzed Efficient Production of Single-stranded DNA Nanostructures.” Chem 2021, 7, 4, 959-981.

• Qingting Li; Zongxuan Tong; Yichun Cao; Hongzhou Gu*. “DNAs catalyzing DNA nanoconstruction.” Chem 2021, 7, 10, 2556-2568.

• Canyu Zhang; Qingting Li; Tianbin Xu; Wei Li; Yungang He; Hongzhou Gu*. “New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem.” Nucleic Acids Research 2021, 49, 11, 6364-6374.

• Xinyu Du^￥; Xiaoqin Cheng^￥; Wei Li; Zhilei Ge; Chunjiu Zhong; Chunhai Fan; Hongzhou Gu*. "Engineering allosteric ribozymes to detect thiamine pyrophosphate in whole blood.” Analytical Chemistry 2021, 93, 9, 4277-4284.

• Tianbin Xu^￥; Canyu Zhang^￥; Kai Xia; Wei Li; Yichun Cao; Hongzhou Gu*. “Small DNAs that bind nickel(II) specifically and tightly.” Analytical Chemistry 2021, 93, 45, 14912-14917.

• Qingting Li; Shu Zhang; Wei Li; Zhilei Ge; Chunhai Fan; Hongzhou Gu*. “Programming CircLigase catalysis for DNA rings and topologies.” Analytical Chemistry 2021, 93, 3, 1801-1810.

• Jin Liu; Hongzhou Gu*. “Biotechnological production of ssDNA with DNA-hydrolyzing deoxyribozymes.” STAR Protocols 2021, 2, 2, 100531.

• Huiyan Li; Fangfei Yin; Xinyi Li; Wannan Jia; Jia Ding; Li Zhang; Zhonghua Wang; Qinqin Hu; Jieliang Zuo; Huliang Jia; Lihua Wang; Chunhai Fan*; Hongzhou Gu*; Jian Wu*. “Novel aptasensor-based assay of sonic hedgehog ligand for detection of portal vein invasion of hepatocellular carcinoma.” Biosensors and Bioelectronics 2021, 174, 112738.

• Dong-Jie Tang^￥; Xinyu Du^￥; Qiang Shi^￥; Jian-Ling Zhang^￥; Yuan-Ping He; Yan-Miao Chen; Zhenhua Ming; Dan Wang; Wan-Ying Zhong; Yu-Wei Liang; Jin-Yang Liu; Jian-Ming Huang; Yun-Shi Zhong; Hongzhou Gu*; Ji-Liang Tang*. “A SAM-I riboswitch with the ability to  sense and respond to uncharged initiator tRNA.” Nature Communications 2020, 11, 2794, 1-11.

• Kai Xia; Jianlei Shen; Qian Li; Chunhai Fan*; Hongzhou Gu*. “Near-Atomic Fabrication with Nucleic Acids.” ACS Nano 2020, 14, 1319-1337.

• Ziyi Wang; Xiao Chu; Na Li; Lingling Fu; Hongzhou Gu*; Nan Zhang*. “Engineered DNA nanodrugs alleviate inflammation in inflammatory arthritis.” International Journal of Pharmaceutics 2020, 577, 119047.

• Zongxuan Tong; Qinqin Hu; Hongzhou Gu*. “Deoxyribozymes: selection, biosensing and outlook.” Chemical Journal of Chinese Universities 2020, 41(11), 2345-2355.

• Qinqin Hu^￥; Hua Li^￥; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanotechnology Enabled Drug Delivery systems.” Chemical  Reviews 2019, 119, 6459-6506.

• Hua Li; Jin Liu; Hongzhou Gu*. “Targeting Nucleolin to Obstruct Vasculature Feeding with An Intelligent DNA Nanorobot.” Journal of Cellular and Molecular Medicine 2019, 23, 2248-2250.

• Xinyu Du^￥; Xin Zhong^￥; Wei Li; Hua Li*; Hongzhou Gu*. “Retraining and Optimizing DNA-Hydrolyzing Deoxyribozymes for Robust Single- and Multiple-Turnover Activities.” ACS Catalysis 2018, 8, 5996-6005.

• Zhilei Ge^￥; Hongzhou Gu^￥; Qian Li; Chunhai Fan*. “Concept and Development of Framework Nucleic Acids.” Journal of the American Chemical Society 2018, 140, 51, 17808-17819.

• Qinqin Hu; Sheng Wang; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides.” Advanced Healthcare Materials 2018, 7, 1701153.

• Hongzhou Gu*. “Single-molecule Genotyping with Nanoscale DNA Shape IDs.” Science China Chemistry 2017, 60, 1111-1112.

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代表性文章（博士-博后期間）

• Hongzhou Gu; Kazuhiro Furukawa; Zasha Weinberg; Daniel F. Berenson; Ronald R. Breaker. “Small, Highly-active DNAs that Hydrolyze DNA.” Journal of the American Chemical Society 2013, 135, 9121-9129.

• Hongzhou Gu; Ronald R. Breaker. “Production of Single-stranded DNAs by Self-cleavage of Rolling-circle Amplification Products.” BioTechniques 2013, 54, 337-343.

• Hongzhou Gu; Kazuhiro Furukawa; Ronald R. Breaker. “Engineered Allosteric Ribozymes that Sense the Bacterial Second Messenger c-di-GMP.” Analytical Chemistry 2012, 84, 4935-4941.

• Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “A Proximity-Based Programmable DNA Nanoscale Assembly Line.” Nature 2010, 465, 202-205.

• Hongzhou Gu; Wei Yang; Nadrian C. Seeman. “DNA Scissors Device Used to Measure MutS Binding to DNA Mis-Pairs.” Journal of the American Chemical Society 2010, 132, 4352-4357.

• Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate.” Nature Nanotechnology 2009, 4, 245-248.

已建成“核酸生物醫(yī)學(xué)工程與技術(shù)”平臺，并形成了包括1名助理研究員、3名博士后、12名博士生、3名科研助理的研究團(tuán)隊，成員多次獲得“上海市超級博士后激勵計劃”、“博士生國家獎學(xué)金”、“上海市優(yōu)秀畢業(yè)生”等獎勵和稱號。

主要專利

•  一種檢測硫胺素焦磷酸的RNA傳感器及其應(yīng)用

       專利號：ZL201810077122.9

       發(fā)明人：顧宏周、杜鑫雨、鐘春玖、程小芹

•  能快速水解DNA的脫氧核酶突變體

       專利號：ZL201810131100.6

       發(fā)明人：顧宏周

•  一種脫氧核酶切割方法

       專利號：ZL201810131087.4

        發(fā)明人：顧宏周

•  提高單鏈DNA連接效率的方法

       專利號：ZL202011011345.9

       發(fā)明人：顧宏周、李青婷

•  一種長單鏈DNA的制備方法

       專利號：201910989379.6

       發(fā)明人：顧宏周、張俏

• 能快速水解DNA的II類脫氧核酶突變體

       專利號：201910989374.3

       發(fā)明人：顧宏周、張俏

• 一種富集、鑒定待測病樣中分子標(biāo)志物的方法

       專利號：202110361337.5

       發(fā)明人：顧宏周、胡沁沁

• 差異篩選特異感應(yīng)三陰性乳腺癌的脫氧核酶探針

       專利號：202110364792.0

       發(fā)明人：顧宏周、胡沁沁

• 一種利用單鏈DNA納米結(jié)構(gòu)輔助分選脂質(zhì)體的方法

       專利號：202010773498.0

       發(fā)明人：顧宏周、陳黎曼

• III類脫氧核酶突變體及其制備方法與應(yīng)用

       專利號：202011120065.1

       發(fā)明人：顧宏周、張燦鈺、李青婷

• IV類脫氧核酶突變體及其制備方法與應(yīng)用

      專利號：202011118638.7

      發(fā)明人：顧宏周、張燦鈺、李青婷

• DNAzyme and use thereof

      專利號：PCT/CN2022/085696

       發(fā)明人：顧宏周、張俏、夏凱、李富友

       申請人：Fudan University；Shanghai Wuti Biotechnology Co., Ltd.

 個人獎項

• 2014年獲評國家級青年人才

• 2017年上海市高層次人才項目

• 2022年上海市優(yōu)秀學(xué)術(shù)帶頭人
  

長期招收博士生、博士后及助理研究員！