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2005.09-2009.07      東華大學(xué)          學(xué)士   導(dǎo)師：王依民 教授

2009.09-2016.02      上海交通大學(xué)   博士   導(dǎo)師：朱新遠 教授

2016.03-2019.09     美國東北大學(xué)                              博士后  導(dǎo)師：張可 教授

2019.10-2022.10     哈佛大學(xué)醫(yī)學(xué)院/麻省理工學(xué)院    博士后  導(dǎo)師：Christopher Weldon 教授 Daniel S. Kohane 教授 Robert S. Langer 教授

2022.11-至今          上海交通大學(xué)   長聘教軌副教授   博士生導(dǎo)師

1.   功能聚合物的可控合成與自組裝

2.   生物材料制備

3.   核酸藥物（例如反義核酸DNA、小干擾RNA、核酸適配體、mRNA等）與蛋白質(zhì)的設(shè)計、遞送及生物醫(yī)用

4.   新型藥物遞送系統(tǒng)、智能醫(yī)療器件的開發(fā)

1.   Wang, D.; Li, Y.; Deng, X.; Torre, M.; Zhang, Z.; Li, X.; Zhang, W.; Cullion, K.; Kohane, D. S.*; Weldon, C. B.*, An aptamer-based depot system for sustained release of small molecule therapeutics. Nat. Commun. 2023, 14, 2444.

2.  Wang, D.; Wang, Q.; Wang, Y.; Chen, P.; Lu X.; Jia, F.; Sun, Y.; Sun, T.; Zhang, L.; Che, F.; He, J.; Lian, L.; Morano, G.; Shen, M.;   Ren, M.; Dong, S.; Zhao, J.*; Zhang, K.*, Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2113180119.

3.  Xu, L.; Yu, C.; Wang, D. *; Pang, J.; Shi, L.; Su, Y.; Gong, L.; Yan, D.; Zhu, X.*, Endogenous nucleotide as drug carrier: base-paired guanosine-5’-monophosphate:   pemetrexed vesicles with enhanced anticancer capability. Sci. China Chem. 2020, 63, 244-253.

4.  Wang, D.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J.; Nyoni, Z.; Lu, X.*; Zhang, K.*, Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo. Sci. Adv. 2019, 5, eaav9322. (Highlighted   in Northeastern News and Science Trends)

5.  Wang, D.; Yu, C.; Xu, L.; Shi, L.; Tong, G.; Wu, J.; Liu, H.; Yan, D.; Zhu, X.*, Nucleoside analogue based supramolecular nanodrugs driven by molecular recognition for synergistic cancer therapy. J. Am. Chem. Soc. 2018, 140, 8797-8806. (Top 15 Biochemistry Discoveries in 2018)

6.  Wang, D.; Liu, B.; Ma, Y.; Wu, C.; Mou, Q.; Deng, H.; Wang, R.; Yan, D.; Zhang, C.*; Zhu, X.*, A molecular recognition approach to synthesize nucleoside analogue based multifunctional nanoparticles for targeted cancer therapy. J. Am. Chem. Soc. 2017, 139, 14021-14024. (Highlighted in Oligonucleotide Therapeutics Society)

7.  Wang, D.; Lu, X.; Jia, F.; Tan, X.; Sun, X.;  Cao, X.; Wai, F.; Zhang, C.*; Zhang, K.*, Precision tuning of DNA-and poly (ethylene glycol)-based nanoparticles via coassembly for effective antisense gene regulation. Chem. Mater. 2017, 29, 9882-9886.

8.  Wang, D.; Jin, Y.; Zhu, X.*; Yan, D.*, Synthesis and applications of stimuli-responsive hyperbranched polymers. Prog. Polym. Sci. 2017, 64, 114-153. (ESI Highly Cited Paper)

9.  Wang, D.; Tu, C.; Su, Y.; Zhang, C.; Greiser, U.; Zhu, X.*; Yan, D.; Wang, W.*, Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery. Chem. Sci. 2015, 6, 3775-3787. (Highlighted in Chemistry World)

10.  Wang, D.; Zhao, T.; Zhu, X.*; Yan, D.; Wang,   W.*, Bioapplications of hyperbranched polymers. Chem. Soc. Rev. 2015, 44, 4023-4071. (ESI Highly   Cited Paper)

專利

1. Ke Zhang, Dali Wang. Carrier-free,   dual-adjuvanted cancer vaccine based on self-assembled DNA amphiphiles. US   Application No. 63/290,797.

2. Ke Zhang, Dali Wang. Poly (ethylene glycol) brushes for efficient RNA delivery. US Application No. 62/646,542.

3. Ke Zhang, Dali Wang. Amphiphilic polymer micelles and use thereof. US Pub. No. US 2018/0369142   A1.

4. 朱新遠，顏德岳，王大力。用于治療腫瘤的兩親性堿基綴合物納米顆粒及其制備方法，專利號ZL201610015514.3；授權(quán)公告日：2018年8月31日

5. 王大力，朱新遠?；诤怂釅A基的超分子磷脂及其制備方法、脂質(zhì)體，專利號：ZL201310349981.6；授權(quán)公告日：2016年6月1日

2021年 國家優(yōu)秀青年科學(xué)基金（海外）

2019年 美國Gordon Research Conference 最佳海報獎

2016年 上海市優(yōu)秀博士畢業(yè)生

歡迎具備化學(xué)、高分子、材料學(xué)、生物醫(yī)學(xué)、藥學(xué)等學(xué)科背景的博士后、博士生、碩士生、本科生加入我們的研究團隊。