電子郵件:[email protected]
個(gè)人主頁: https://chembiophys.sjtu.edu.cn/index.html
2013.09?2017.06 南京大學(xué),物理學(xué),博士,導(dǎo)師:王煒教授、曹毅教授
2009.09?2013.06 南京大學(xué),物理學(xué)(生物物理),學(xué)士
2023.11至今 上海交通大學(xué),化學(xué)化工學(xué)院,長聘教軌副教授
2020.01?2023.10 新加坡國立大學(xué),物理系和力生物學(xué)研究所,博士后,合作導(dǎo)師:Jie Yan 教授
2017.07?2019.12 南京大學(xué),化學(xué)化工學(xué)院,博士后,合作導(dǎo)師:曹毅 教授
化學(xué)、物理和生物交叉的單分子和單細(xì)胞力學(xué):
1)發(fā)展單分子和單細(xì)胞力學(xué)技術(shù)(基于原子力顯微鏡、磁鑷、玻璃微管和微流控的多尺度力學(xué)技術(shù));
2)發(fā)展宏量和高通量力學(xué)技術(shù),結(jié)合機(jī)器學(xué)習(xí),實(shí)現(xiàn)分子和細(xì)胞力學(xué)編程;
3)研究機(jī)械力介導(dǎo)的化學(xué)反應(yīng)(力增強(qiáng)反應(yīng);力化學(xué)生物學(xué);高分子物理和力化學(xué);核酸力化學(xué))
4)研究機(jī)械力調(diào)控的分子和細(xì)胞生物學(xué)(力生物學(xué);生物大分子的力致構(gòu)象轉(zhuǎn)變、相互作用與黏附;蛋白質(zhì)錯(cuò)誤折疊與神經(jīng)退行性疾?。?/p>
2023 國家海外高層次引進(jìn)人才計(jì)劃
2023 上海市海外高層次引進(jìn)人才計(jì)劃
2025-2029 國自然面上項(xiàng)目
2025-2028 國家重點(diǎn)研究計(jì)劃 培育項(xiàng)目
1. Wenmao Huang, et al. Ions shaping the mechanics of chromosomes in mitosis, Nat. Mater. 2024, 23, 1468–1470
2. Linfeng Yang,..., Chunhai Fan*, Wenmao Huang*. DNA Mechanics: From Single Stranded to Self-Assembled. Nano Letts, 2024, 24, 38, 11768-11778
before SJTU:
1. Wenmao Huang*, et al. In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates
of monomeric α-synuclein. APL Bioengineering, 2024, 8 (1) (一作+共通,F(xiàn)eatured Article)
2. Chaoyu Fu#, Wenmao Huang#, et al., Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs.
Nano. Lett.. 2023, 23, 20, 9179–9186.
3. Wenmao Huang, et al. Mechanical stabilization of a bacterial adhesion complex. J. Am. Chem. Soc., 2022, 144, 37, 16808-16818.
4. Wenmao Huang, et al. Maleimide–thiol adducts stabilized through stretching. Nat. Chem., 2019, 11, 310–319.
(Highlighted by Nat. Chem. "Pulling together to improve stability").
5. Weishuai Di#, Xiang Gao#, Wenmao Huang#, et al. Direct measurement of length scale dependence of the hydrophobic free energy of
a single collapsed polymer nanosphere. Phys. Rev. Lett., 2019, 122, 047801.
6. Wenmao Huang#, Zhenshu Zhu#, Jing Wen#, et al. Single Molecule Study of Force-Induced Rotation of Carbon–Carbon Double Bonds in Polymers.
ACS Nano, 2017, 1, 194-203 (Highlighted by “Twist and Shout: Single-Molecule Mechanochemistry”).
7. Xingdong Guo#, Chengsong Yan#, Hua Li#, Wenmao Huang#, et al. Lipid-dependent conformational dynamics underlie the functional versatility of
T-cell receptor. Cell Res., 2017, 27, 505-525.
8. Wenmao Huang, et al. Profiling selective binding to promoter CpG islands by a single-DNA mechanical footprinting assay.
Biophys. J., 2021, 16, 3235-3236.
9. X. Wu#, Wenmao Huang#, W.-H. Wu# et al. Reversible hydrogels with tunable mechanical properties for optically controlling cell migration.
Nano Res., 2018, 11, 5556–5565.
10. Wenmao Huang, et al. Dimerization of cell-adhesion molecules can increase their binding strength. Langmuir, 2017, 6, 1398-1404.
書籍列表
11. Wenmao Huang, Yi Cao*, et al. Single-molecule Atomic Force Microscopy, 軟物質(zhì)前沿科學(xué)叢書, 2021 (基于原子力顯微鏡的單分子技術(shù)).
12. Wenmao Huang, Jie Yan*, et al. Micropipette-based single-cell mechanical quantification. Methods Mol. Biol. Springer, 2022
(基于玻璃微管的單細(xì)胞操控技術(shù)).
已發(fā)表文章列表(Google Scholar): https://scholar.google.com.sg/citations?user=HO5APLkAAAAJ&hl=zh-CN
Supramolecular Materials 青年編委(2024)
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讓我們一起懷著好奇心,從物理學(xué)本質(zhì)規(guī)律出發(fā),通過操控與測(cè)量單個(gè)分子、單個(gè)細(xì)胞的力學(xué)行為,揭開隱藏在化學(xué)和生物學(xué)中的種種奧秘!
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