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2007.09 - 2013.07 北京大學，前沿交叉學科研究院，博士

2002.09 - 2006.07 南昌大學，生命科學學院，學士

2018.07 -2023.06 耶魯大學，分子生物物理學與生物化學系，研究科學家

2014.07 -2018.07 耶魯大學，細胞生物學系，博士后

核酸與蛋白質(zhì)納米裝置設計、組裝與應用；

DNA納米反應器設計與應用；

DNA納米通道設計與應用

國家海外高層次引進人才計劃，2024-2026，主持

1.     Q. Shen, Q. Feng, Q. Xiong, C. Wu, Y. Yuan, T. Tian, S. Yuan, J. Temple, C. Aiken, A.N. Engelman, C.P. Lusk, C. Lin, and Y. Xiong, "Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels",  Nature Structural & Molecular Biology, 2023, 30, 425-435.

2.     P. Zhan, A. Peil, Q. Jiang, D. Wang, S. Mousavi, Q. Xiong, Q. Shen, Y. Shang, B. Ding, C. Lin, Y. Ke, and N. Liu. "Recent Advances in DNA Origami-Engineered Nanomaterials and Applications", Chemical Reviews, 2023, 123, 3976-4050

3.     Q. Shen, S. Kumari, C. Xu, S. Jang, J. Shi, R.C. Burdick, L. Levintov, Q. Xiong, C. Wu, S.C. Devarkar, T. Tian, T.N. Therese, Y. Hu, S. Yuan, J. Temple, Q. Feng, P. Lusk, C. Aiken, A.N. Engelman, J. Perilla, V.K. Pathak, C. Lin, and Y. Xiong, "The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores", Proc Natl Acad Sci USA, 2023, 120, e2202815120.

4.     W. Luo, V. Demidov, Q. Shen, H. Gir?o, M. Chakraborty, A. Maiorov, F. Ataullakhanov, C. Lin, H. Maiato, E. Grishchuk. "CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide-state sensitive manner", Science Advances, 2023, 9, eabq5404.

5.     Q. Shen^#, Q. Xiong^#, K. Zhou, Q. Feng, L. Liu, T. Tian, C. Wu, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity", J Am Chem Soc, 2023, 145, 1292–1300.

6.     Q. Shen, C. Wu, C. Freniere, T. N. Tripler, Y. Xiong. "Nuclear Import of HIV-1", Viruses, 2021, 13, 2242

7.     Q. Shen, T. Tian, Q. Xiong, P.D.E. Fisher, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins", J Am Chem Soc, 2021, 143, 12294-12303.

8.     Q. Shen and C. Lin. "RNA returns to the fold", Nature Chemistry, 2020, 12, 221-222.

9.     Y. Hu, K. Knecht, Q. Shen, Y. Xiong, "Multifaceted HIV-1 Vif interactions with Human E3 Ubiquitin Ligase and APOBEC3s". FEBS J., 2020, 288, 3407-3417.

10.  S. Yuan, L Peng, J. J. Park, Y. Hu, S. C. Devarkar, M. B. Dong, Q. Shen, S. Wu, S. Chen, I. B. Lomakin, and Y. Xiong. "Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA",  Molecular Cell, 2020, 80, 1-12.

11.  Q. Xiong, C. Xie, Z. Zhang, L. Liu, J. Powell, Q. Shen, and C. Lin, "DNA Origami Post-Processing by CRISPR-Cas12a", Angew Chem Int. Edit, 2020, 59, 3956-3960.

12.  J. Temple^#, T.N. Tripler^#, Q. Shen^#, Y. Xiong. "A snapshot of HIV-1 capsid–host interactions", Curr Res Struct Biol, 2020, 2, 222-228.

13.  Q. Shen, M.W. Grome, Y. Yang, and C. Lin. "Engineering Lipid Membranes with Programmable DNA Nanostructures", Adv Biosyst, 2020, 4, 1900215.

14.  P. Fisher^#, Q. Shen^#, B. Akpinar, L. Davis, K. Chung, D. Baddeley, A. ?ari?, T. Melia, B. Hoogenboom, C. Lin, and P. Lusk. "A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement", ACS Nano, 2018, 2, 1508-1518. 

15.  Q. Shen^#, C. Zhang^#, J. Cao, Y. Liu, Y. Liang, M. Zhao, and L. Lai. "De novo design of helical peptides to inhibit TNFα by disrupting its trimer formation", MedChemComm, 2016, 7, 725-729.

16.  Q. Shen^#, J. Chen^#, Q. Wang, X. Deng, and L. Lai. "Discovery of highly potent TNFα inhibitors using virtual screening", Eur J Med Chem, 2014, 65, 119-126.

17.  G. Stanley, B. Akpinar, Q. Shen, PDE. Fisher, C.P. Lusk, C. Lin, and B. Hoogenboom, "Quantification of Biomolecular Dynamics Inside Real and Synthetic Nuclear Pore Complexes Using Time-Resolved Atomic Force Microscopy", ACS Nano, 2019, 13, 7949-7956.

18.  C. Zhang^#, Q. Shen^#, B. Tang, and L. Lai. "Computational design of helical peptides targeting TNFα", Angew Chem Int Edit, 2013, 52, 11059-11062.

2023年，羅伯特德克斯分子編程獎，國際納米科學、計算和工程學會

2023年，國家高層次青年人才計劃

長期招收來自生物、化學、醫(yī)學、生物醫(yī)學工程、計算機等跨學科領域的本科生、研究生和博士后，歡迎有志于從事高水平創(chuàng)新研究的同學加入！